PDE4B-IN-2 Size:Contact [email protected] for quotation crustaceans (Daphnia magna)

crustaceans (Daphnia magna)

Smiles: COC1=CC(=CC(OC)=C1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(C2=C(SC(C)=C2C)N2C1=NN=C2C)C1C=CC(Cl)=CC=1)/N=N/C1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O

24(17):4236-8

Similarly in the proliferation assay

PDE4B-IN-2 Size:Contact [email protected] for quotation crustaceans (Daphnia magna)PDE4B IN 2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100 fold selectivity for PDE4B over 4D. PDE4B IN 2 regulates cAMP in inflammatory cells and inhibits LPS induced TNF production and neutrophil accumulation in mouse lungs. PDE4B IN 2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B IN 2 also exhibits antidepressant like effects. Product